Nickel-catalyzed deaminative Sonogashira ka hui ʻana o nā paʻakai alkylpyridinium i hoʻohana ʻia e NN2 pincer ligand

Loaʻa nui ʻia nā Alkynes i nā huahana kūlohelohe, nā molekole olaola a me nā mea hana kūlohelohe.I ka manawa like, he mau mea koʻikoʻi nō hoʻi lākou i ka synthesis organik a hiki ke hana i nā hopena hoʻololi kemika nui.No laila, ʻo ka hoʻomohala ʻana i nā ʻano hana hana alkynes maʻalahi a pono hoʻi.ʻOiai ʻo ka pane ʻana o Sonogashira i hoʻopaʻa ʻia e nā metala hoʻololi ʻo ia kekahi o nā ala kūpono a maʻalahi hoʻi e synthesize i ka aryl a i ʻole alkenyl substituted alkynes, ʻo ka hoʻohui ʻana e pili ana i nā electrophiles alkyl i hoʻāla ʻole ʻia ma muli o nā hopena ʻaoʻao e like me ka hoʻopau ʻana i ka bH.Paʻa mau i nā pilikia a me ka liʻiliʻi o ka noiʻi, i kaupalena ʻia i nā alkanes halogenated pili ʻole i ke kaiapuni.No laila, ʻo ka ʻimi ʻana a me ka hoʻomohala ʻana o ka pane ʻana o Sonogashira o nā mea hou alkylation reagents, maʻalahi a maʻalahi ke loaʻa i mea koʻikoʻi nui ma ka synthesis laboratory a me nā noi ʻoihana.Ua hoʻolālā akamai a hoʻomohala ka hui i kahi ligand amide-type NN2 pincer ligand hou, maʻalahi a paʻa, a no ka manawa mua i ʻike i ka maikaʻi a me ke koho kiʻekiʻe o nā alkylamine derivatives a me nā alkynes terminal me kahi ākea o nā kumu catalytic nickel, maʻalahi a maʻalahi hoʻi. loaa.Ua hoʻohana maikaʻi ʻia ka hopena hoʻohui i ka deamination hope a me ka hoʻololi ʻana o ka alkynylation o nā huahana kūlohelohe paʻakikī a me nā molekala lāʻau, e hōʻike ana i ka hana maikaʻi a me ka hui pū ʻana o ka hana, a hāʻawi i nā mea hou no ka synthesis o nā alkyl-substituted alkynes koʻikoʻi.A me nā ʻano hana.